Description
Surface Plasmon Resonance (SPR) is a well-established technique for studying biomolecular interactions. It is valued for its high sensitivity and its ability to provide real-time, label-free measurements.
The Multi-Parametric Surface Plasmon Resonance (MP-SPR) technology builds upon these same principles but features an advanced optical configuration that enables the recording of the entire SPR curve. This approach offers a more comprehensive understanding of interaction processes and delivers new structural and kinetic insights.
In addition to interaction studies, MP-SPR provides unique information about film and surface properties, including thickness and refractive index (RI), which are essential for material characterization or for verifying the molecular conformation on the surface. Moreover, the system can be integrated with an electrochemical flow cell, further expanding its experimental capabilities.
Thanks to the PureKinetics™ function, MP-SPR can analyze small molecules, lipids, and biomaterials while eliminating bulk-related artifacts (such as the DMSO effect). Its versatility extends the capabilities of traditional SPR — from small molecules to nanoparticles, viruses, and living cells — and allows measurements even in complex media such as serum or cell samples.
Main Applications:
- Study of biomolecular interactions: protein-ligand, receptors, antibodies, kinetic studies
- Biosensor development: interface optimization, surface functionalization
- Analysis of thin films and coatings: materials, biomaterials, coatings, nanostructures
- Characterization of nanoparticles, liposomes, viruses, complex systems for nanotechnology
- Measurements on living cells: adhesion, uptake, response to external stimuli
- Characterization of extracellular vesicles (EVs)
